Witepsol®H15 is an NF grade, small pastille form suppository base comprised of glycerides from vegetable origins with a long history of use with a wide range of APIs. PEG bases. fatty bases. List and describe a variety of suppository bases. Supposi-Plex™ V33 Suppository Base Supposi-Plex V33 is a pellet form, easy to use compounding suppository base that is derived from vegetable and fatty alcohol origins. Describe three (3) methods of suppository preparation. Describe the proper formulation, packaging, and administration of suppository bases. -Emulsified Theobroma oil maybe used as base when large quantities of aqueous solutions are to be incorporated. There are three types of suppositories, each to insert into a different orifice: Rectal suppositories into the rectum, vaginal suppositories into the vagina, and urethral suppositories into the urethra of a male They are chemically stable, nonirritating, miscible with water and mucous secretions, and can be formulated, either by molding or compression, in a wide range of hardness and melting point. Suppository bases. Wecobee bases: triglycerides derived from coconutoil. 2.3. Measurement of gelation temperature. It's a small, round or cone-shaped object that you put in your body, often into your bottom. Oleaginous (fatty or hydrophobic) bases. Liquid suppository bases were kept at 4°C prior to use. water/base partition coefficient. Acta Pol Pharm. The six general classes of suppository bases identified by the USP are described here. Insert the suppository into the rectum, narrow end first. Solubility: Witepsol®H15 is readily soluble in diethylether, toluene and … Gently but firmly, push the suppository past the sphincter. Examples of Macrogol bases: I II III IV Macrogol 400 Macrogol 1000 Macrogol 1540 Macrogol 4000 Macrogol 6000 Water - - - 33 47 20 - - 33 - 47 20 20 - 33 - 47 - - 75 - 25 - - By choosing a suitable combination a suppository base with the desired characteristics can be prepared. A review of the literature on suppository bases shows that much work has been done on fattype bases such as cocoa butter.Some investigations have been made on water‐soluble and emulsion type bases. Specifications of suppository bases. The influence of suppository bases upon the rectal absorption of acetylsalicylic acid. There seems to be little or no work done with such compounds as plastics, synthetic resins, and other similar condensation products. 1.2 Relationship between dossier specifications and the Pharmacopoeia Page 7 8. 1. SUPPOSITORY BASES: Solid form at room temp. [Determination of the course of melting and solidification of suppository bases]. 1974;31(5):651-6. Standard suppository molds offer challenges to compounders, because they are time consuming both to use and to clean. It is contains the drugs which are used in treatment of the infections of female genitourinary tract and meant for contraception. Advantages: 1. What is the main prereq for a suppository base? Suppository bases may be classified according to their composition and physical properties: 1- Oleaginous (fatty) bases 2- Water soluble or miscible bases 37 3- Miscellaneous Bases Specifications of suppository bases 1- Origin and chemical composition The source of origin (i.e. entirely natural or synthetic or modified natural). [Article in Italian] -5% Glyceryl monostearate, 10% Lanette wax, 2_3% cetyl alcohol &4% bees wax is recommended for emulsified Theobroma oil. Synonyms for Suppository bases in Free Thesaurus. It is about 3-5g in weight. At least those aspects considered to be critical should be the object of specifications routinely verified. A suppository is another way to deliver a drug. Suppository Bases Sort by Sort by Show 24 36 48 View as from $32.00. bases also have low hydroxyl values (15 < 6 < 6) when compared to others, it is possible to explain the high release percentage of the active substance C31G from the vaginal suppositories prepared using these bases. The sphincter is the muscular opening of the rectum. Some properties of fatty suppository bases Acid content Hydroxyl number Iodine number Cocoa butter <5 0 34-38 Semi-synthetic fatty bases … • Water soluble bases—for example, polyethylene glycols— that dissolve in the anorectal fluids release for absorption 1973 Feb;112(2):116-33. These are made with best quality material and have sodium stearate as a component. We offer a wide range of suppository bases. 4- Saponification value ; The number of milligrams of potassium hydroxide required to neutralize the free acids and to saponify the esters contained in 1 gm of fat is an indication of the type of glyceride (mono- or tri-) as well as the amount of glyceride present. [Stability of drugs in lyophilic suppository bases. Backed by vast experience, we manufacture and supply a wide gamut of Suppository Bases. Suitable for both rectal and vaginal use. Emulsified cocoa butter. Boll Chim Farm. Suppository bases play an important role in the release of medication they hold and the availability of the drug. 4 words related to suppository: medicament, medication, medicinal drug, medicine. Oleaginous bases include theobroma oil (also called cocoa butter) and synthetic triglyceride mixtures. Determine the density factor of a drug in polyethylene glycol suppositories. 21 Specifications of suppository bases For adults, push it … Fat-type suppository bases can be produced from a variety of vegetable oils, such as coconut or palm kernel, which are modified by esterification, hydrogenation, and fractionation to obtain products of varying composition and melting temperatures (e.g., Hydrogenated Vegetable Oil and Hard Fat).These products can be so designed as to reduce rancidity. selection of suppository bases depends on. the release fo a drug from a fatty, lipophilic suppository base to the aqueous medium in the rectum depends on the _____ of the drug. 1. suppository bases in a sentence - Use "suppository bases" in a sentence 1. Table 1: Evaluation of the partitioning of C31G between various suppository bases/pH 8 buffer and chloroform/pH 8 buffer (n = 3) • A lipophilic drug that is distributed in a fatty suppository base in low concentration has less tendency to escape to the surrounding aqueous fluids than a hydrophilic substance in a fatty base. A suppository is a pill or medication that is inserted through the rectal area of the body. 1.1.1. Polyethylene Glycol Polymers have received much attention as suppository bases in recent years because they possess many desirable properties. are preferred for vaginal and urethral supposiories. Anthony F. Cacchillo. It is contains the combination of polyethylene glycol of different molecular weights as suppository bases. are preferred for rectal suppositories. Oily bases or oleoginous bases 1.1. 15 -25oC and melts at body temp (for oil based suppositories) • Amorphous, smooth, non-irritating vehicle • Medicinally inert without side effects Types: Oleaginous (fatty/oily) bases (lipophilic) Theobroma Oil (cocoa butter) & synthetic triglyceride mixtures o Water soluble bases (hydrophilic) Suppository base excipients are used in the manufacture of suppositories (for rectal administration) and pessaries (for vaginal administration). Types of suppository bases by Hadeer Zedan 1. A 20-ml transparent vial containing a magnetic bar and 10 g of liquid suppository base was placed in a low-temperature thermostat water bath (Heto, Scandinavia). An appropriate specification for each aspect of quality studied during the phase of development and during the validation of the manufacturing process should be determined. Witepsol bases: triglycerides of saturated fatty acids C12–C18, their melting ranges vary from 32 - 42 oC . University of Tennessee School of Pharmacy Memphis, Tenn. Graduate student in Hospital Pharmacy, University of Tennessee School of Pharmacy. Suppository bases usually used are theobroma oil, glycerinated gelatin, hydrogenated vegetable oils, mixtures of polyethylene glycols of various molecular weights, … Suppository bases can be classified as according to their composition and physical properties. A problem that both compounders and patients face is the burdensome process of removing suppositories from outdated molds, whether they’re from bulky metal trays or the peel-away plastic suppository shells. Home Suppository Bases. Identify the best product for your purpose and ask the related technical sheet to our team which will be pleased to help you. INTRODUCTION Physicians, pharmacists and patients generally do not appreciate the use of suppositories although this dosage fomi has many clinical advantages, similarly the drug release from the suppositories bases and factors influencing the drug release have not been fully established. What are synonyms for Suppository bases? V. Identification of products of ethionamide decay isolated from suppositories]. Search for more papers by this author. A suppository can be introduced into any absorbent orifice of the body,such as the vagina. Prepare suppositories by the fusion (molding) technique. Antonyms for Suppository bases. A suppository is a dosage form used to deliver medications by insertion into a body orifice where it dissolves or melts to exert local or systemic effects. (C) VAGINAL SUPPOSITORY It is in oviform shape. Important characteristics for suppositories include (1) hardness (for proper handling and delivery), (2) shape (for comfortable insertion and retention), (3) solubilization of drug in suppository matrix, and (4) rapid melting after application. They are used commercially in numerous applications, including as surfactants, in foods, in cosmetics, in pharmaceutics, in biomedicine, as dispersing agents, as solvents, in ointments, in suppository bases, as tablet excipients, and as laxatives. but soften, melt or dissolve readily at body temp; so … A suppository base must remain solid at room temp. , often into your bottom and synthetic triglyceride mixtures is contains the drugs which are used in treatment of body. 24 36 48 View as from specifications of suppository bases 32.00 of products of ethionamide decay isolated from suppositories ] suppositories by USP... Is another way to deliver a drug in polyethylene glycol suppositories related to suppository: medicament, medication, drug... 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